The early symptoms of diabetes

Typical symptoms
A large class of performance related to metabolic disorders, especially related to high blood sugar "a little more common in type 1 diabetes, type 2 diabetes often is not very clear or only part of the performance;
(1) polyuria
Exceed the renal threshold for glucose (8.89 ~ 10.0mmol / L), hyperglycemia, glucose, glomerular filtration can not be completely tubular reabsorption, the formation of osmotic diuresis. Higher blood sugar, urine sugar excretion more, more urine, 24h urine output up to 5000 ~ 10000ml. However, the elderly and those with kidney disease, increased renal threshold for glucose, urine excreted in blood sugar with mild to moderate hypertension, polyuria is not obvious.
2 drink
Mainly due to hyperglycemia plasma osmolality was significantly higher, in addition to polyuria, excessive water loss, the occurrence of intracellular dehydration and aggravate high blood glucose, plasma osmolality was significantly increased further stimulate the thirst center, resulting in thirst, polydipsia. Drink to further aggravate the urine.
3 more food
The polyphagia mechanism is not very clear. Most scholars tend to (out of the tissue cells before and after the arterial and venous blood glucose concentration) due to reduced glucose utilization. Normal fasting moving venous blood concentrations of glucose deficit, stimulate the feeding center, resulting in hunger; elevated blood glucose after ingestion, arterial and venous concentration difference increase (greater than 0.829mmoL / L), feeding center inhibition, full abdominal central nervous system stimulation, feeding requirements disappear. However, people with diabetes an absolute or relative insulin deficiency or organization is not sensitive to insulin, tissue uptake is decreased by using glucose ability, although the blood sugar at a high level, but the difference is small arterial and venous blood glucose concentration, tissue cells are actually in the "hungry so as to stimulate the feeding center, causing hunger, eat; In addition, the body can not make full use of glucose, a large number of glucose from the urine excretion, the body is actually in a semi-starvation, lack of energy has also aroused the appetite, hyperactivity.
(4) weight loss
Patients with diabetes appetite and food intake to normal or even increased, but the weight loss, mainly due to absolute or relative insulin deficiency or insulin resistance, the body can not make full use of the glucose to produce energy, resulting in fat and protein decomposition strengthen consume excessive amounts of negative nitrogen balance , the weight gradually decreased, and even weight loss. Diabetes upon reasonable treatment, good control, weight loss can be controlled, and even picked up. Such as the weight of the diabetic patients during treatment continued to decline or significant weight loss, suggesting that may be of poor metabolic control or associated with other chronic wasting disease.
5, fatigue
Is also common in patients with diabetes, glucose can not be completely oxidized and that the body can not make full use of glucose and release energy, while the organization of dehydration, electrolyte imbalance and negative nitrogen balance, and thus feel the malaise, listlessness.